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Structural Bioinformatics Online Exam Quiz

Important questions about Structural Bioinformatics. Structural Bioinformatics MCQ questions with answers. Structural Bioinformatics exam questions and answers for students and interviews.

The building blocks of proteins are ______ naturally occurring amino acids, small molecules that contain a free amino group (NH?) and a free carboxyl group (COOH).

Options

A : a. ten

B : b. twenty

C : c. nine

D : d. nineteen

Within the hydrophobic set of amino acids, they can be further divided into aliphatic and aromatic.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

______ the smallest amino acid, has a hydrogen atom as the R group.

Options

A : a. valine

B : b. proline

C : c. Glycine

D : d. threonine

The peptide formation involves two amino acids covalently joined together between the carboxyl group of one amino acid and the amino group of another.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

A linear polymer of more than fifty amino acid residues is referred to as a ________

Options

A : a. dipeptide

B : b. oligopeptide

C : c. peptide

D : d. polypeptide

Which of the following is not correct about the stabilizing Forces?

Options

A : a. Protein structures from secondary to quaternary are maintained by noncovalent forces

B : b. They include electrostatic interactions but not van der Waals forces, and hydrogen bonding

C : c. Electrostatic interactions are a significant stabilizing force in a protein structure

D : d. Electrostatic interactions occur when excess negative charges in one region are neutralized by positive charges in another region

Which of the following is not correct about the ?-Helices?

Options

A : a. An ?-helix has a main chain backbone conformation that resembles a corkscrew

B : b. Nearly all known ?-helices are right handed, exhibiting a leftward spiral form

C : c. Nearly all known ?-helices are right handed, exhibiting a rightward spiral form

D : d. In right handed helix, there are 3.6 amino acids per helical turn

Which of the following is not correct about the ?-sheet?

Options

A : a. A ?-sheet is a fully extended configuration built up from several spatially adjacent regions of a polypeptide chain

B : b. Each region involved in forming the ?-sheet is a ?-strand

C : c. The ?-strand conformation is pleated with main chain backbone zigzagging and side chains positioned on same sides of the sheet

D : d. ?-Strands are stabilized by hydrogen bonds between residues of adjacent strands

Which of the following is not correct about the Coils and Loops?

Options

A : a. They are regular structures

B : b. They are irregular structures

C : c. The loops are often characterized by sharp turns or hairpin-like structures

D : d. If the connecting regions are completely irregular, they belong to random coils

Globular proteins are usually insoluble.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

Which of the following is not correct about the Integral Membrane Proteins?

Options

A : a. Membrane proteins exist in lipid bilayers of cell membranes

B : b. The exterior of the proteins spanning the membrane must be very hydrophobic to be stable

C : c. The exterior of the proteins spanning the membrane must be very hydrophilic to be stable

D : d. Most typical transmembrane segments are ?-helices

Which of the following is not correct about the X-ray Crystallography?

Options

A : a. In x-ray protein crystallography, proteins need to be grown into large crystals in which their positions are fixed in a repeated, ordered fashion

B : b. The protein crystals are illuminated with an intense x-ray beam

C : c. The x-rays are deflected by the electron clouds surrounding the atoms in the crystal producing a regular pattern of diffraction

D : d. The protein crystals are illuminated with an intense infrared beam

Which of the following is not correct about the NMR?

Options

A : a. It stands for Nuclear Magnetic Resonance

B : b. NMR spectroscopy detects spinning patterns of atomic nuclei in a electric field

C : c. NMR spectroscopy detects spinning patterns of atomic nuclei in a magnetic field

D : d. Protein samples are labeled with radioisotopes such as 13C and 15N

One can search a structure in PDB using the four-letter code or keywords related to its annotation.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

The main feature of computer visualization programs is interactivity, which allows users to visually manipulate the structural images through a graphical user interface.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

A Protein Data Bank (PDB) data file for a protein structure contains only x, and z coordinates of atoms.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

A wire-frame diagram is a line drawing representing bonds between atoms.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

Balls and sticks are solid spheres and rods, representing atoms and bonds, respectively.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

Ribbon diagrams use cylinders or spiral ribbons to represent ?-helices and broad, flat arrows to represent ?-strands.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

Different representation styles can be used in combination to highlight a certain feature of a structure while deemphasizing the structures surrounding it.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

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