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Genomics and Proteomics Online Exam Quiz

Important questions about Genomics and Proteomics. Genomics and Proteomics MCQ questions with answers. Genomics and Proteomics exam questions and answers for students and interviews.

Which of the following is untrue about the genome mapping?

Options

A : a. It doesn’t lead to the understanding of a genome structure

B : b. It involves identifying relative locations of genes

C : c. It involves identifying traits

D : d. It involves identifying mutations

Genetic markers are ______ portions of a _______ whose inheritance patterns can be followed.

Options

A : a. unidentifiable, genes

B : b. unidentifiable, chromosome

C : c. identifiable, chromosome

D : d. identifiable, genes

Genetic linkage maps, also called genetic maps, identify the relative positions of genetic markers on a chromosome and are based on how frequent the markers are inherited together.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

One centiMorgan is defined as _________ percentage of the total recombination events.

Options

A : a. one

B : b. ten

C : c. 0.1

D : d. 0.01

Physical maps are maps of locations of identifiable landmarks on a genomic DNA _______ inheritance patterns.

Options

A : a. remotely related to

B : b. related to

C : c. regardless of

D : d. associated with

Physical maps are constructed by using a chromosome walking technique.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

Which of the following is untrue about cytologic maps?

Options

A : a. They cannot be directly observed under microscope

B : b. They refer to banding patterns

C : c. They can be viewed on stained chromosomes

D : d. They can be directly observed under microscope

Cytologic maps can be considered to be of _____ resolution and hence somewhat ______ physical maps.

Options

A : a. very high, inaccurate

B : b. very low, accurate

C : c. very high, accurate

D : d. very low, inaccurate

In medical applications, the ultimate goal of gene mapping is to disease genes.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

One of the fundamental events that occur in meiosis is crossing over in which homologous chromosomes exchange segments causing a reshuffling of genes.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

The _____ resolution genome map is the genomic DNA sequence that can be considered as a type of ______ map describing a genome at the single base-pair level.

Options

A : a. highest, physical

B : b. lowest, physical

C : c. highest, cytological

D : d. lowest, cytological

Which of the following is untrue about DNA sequencing?

Options

A : a. It is now routinely carried out using the Sanger method

B : b. This doesn’t make use of DNA polymerases

C : c. This involves the synthesis of DNA chains of varying length

D : d. The DNA synthesis is stopped by adding dideoxynucleotides

In DNA sequencing, the fluorescent traces of the DNA sequences are read by a computer program that assigns bases for each peak in a chromatogram.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

The shotgun approach _______ sequences clones from _____ of cloned DNA.

Options

A : a. randomly, one end

B : b. randomly, both ends

C : c. specifically, both ends

D : d. specifically, one end

The shotgun approach does not require knowledge of physical mapping of the clone fragments, but rather a robust computer assembly program to join the pieces of random fragments into a single, whole-genome sequence.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

Despite the multiple coverage, sometimes certain genomic regions remain unsequenced, mainly owing to cloning difficulties.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

The hierarchical genome sequencing approach is ______

Options

A : a. entirely dissimilar to the shotgun approach

B : b. dissimilar to the shotgun approach

C : c. similar to the shotgun approach, but on a larger scale

D : d. similar to the shotgun approach, but on a smaller scale

In hierarchical genome sequencing approach, based on the results of _______ mapping _______of the BAC clones on a chromosome can be determined.

Options

A : a. physical, the locations and orders

B : b. physical, only the locations

C : c. cytological, only the locations

D : d. physical, only the orders

The hierarchical approach is ____ and _____ than the shotgun approach because it involves an initial clone-based physical mapping step.

Options

A : a. slower, less costly

B : b. faster, more costly

C : c. faster, less costly

D : d. slower, more costly

The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.

Options

A : a. True

B : b. False

C : c. May be True or False

D : d. Can't say

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