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Downstream Processing Online Exam Quiz

Important questions about Downstream Processing. Downstream Processing MCQ questions with answers. Downstream Processing exam questions and answers for students and interviews.

1. A typical tubular centrifuge has a bowl of 2 to 5 inch in diameter and 9 to 30 inch in height with a maximum rotating speed of

Options

A : 15,000 to 50,000 rpm

B : 50,000 to 100,000 rpm

C : 100,000 to 150,000 rpm

D : 150,000 to 200,000 rpm

2. The disk centrifuge is the type of centrifuge used most often for bio separations due to its

Options

A : continuous operation

B : lesser cost

C : higher speed

D : ease in operation

3. Which of the following is not the physical method for the cells rupturing?

Options

A : Milling

B : Homogenization

C : Ultrasonication

D : Enzymatic digestion

4. The optimum wet solid content for the cell suspension for a bead mill is typically somewhere between

Options

A : 5-15% by volume

B : 15-30% by volume

C : 30-60% by volume

D : 60-90% by volume

5. The effectiveness of a solvent can be measured by the

Options

A : distribution coefficients

B : selectivity

C : both (a) and (b)

D : diffusivity

6. A system which require less solvent and produces a more concentrated extract phase, is desired with a

Options

A : large distribution coefficients

B : small distribution coefficients

C : very small distribution coefficients

D : constant distribution coefficients

7. If the membrane rejects all solute, the rejection coefficient (s) is

Options

A : 1

B : 0

C : >1

D : <1

9. Filtration leaf test results indicate that the filtration rate of a protein product is 100 dry lbs/(ft 2 hr). What size production filter would be required to obtain 100 dry lbs of filter cake/hr?

Options

A : 1.54 ft 2

B : 3.08 ft 2

C : 65 ft 2

D : 65 lbs/ ft 2 .hr

10. Which of the operation does not come under upstream processing?

Options

A : Media preparation

B : Inoculum development

C : Effluent treatment

D : Storage of raw material

1. In antibiotic manufacturing processes, the fermentation time ranges from

Options

A : 2-3 weeks

B : 1-2 weeks

C : 4-5 weeks

D : 2-4 weeks

2. Chromatography is based on the

Options

A : different rate of movement of the solute in the column

B : separation of one solute from other constituents by being captured on the adsorbent

C : different rate of movement of the solvent in the column

D : any of the above

3. A common filter medium is the cloth filter generally made of

Options

A : canvas

B : synthetic fabrics

C : metal or glass fiber

D : all of these

4. Maintenance cost varies from

Options

A : 0-4% of the capital cost

B : 12-16% of the capital cost

C : 4-8% of the capital cost

D : 8-12% of the capital cost

5. The stage wise operation of adsorption is called

Options

A : contact filtration

B : conventional adsorption

C : affinity adsorption

D : ion exchange

6. The purity of a solute collected between two times t 1 and t 2 during chromatographic separation can be calculated as

Options

A : amount of solute eluted - amount of impurity eluted

B : amount of solute eluted / amount of impurity eluted

C : amount of solvent eluted + amount of impurity eluted

D : amount of solvent eluted / amount of impurity eluted

7. Start up expenses in a fermentation industry varies from

Options

A : 0-5% of the capital cost

B : 10-15% of the capital cost

C : 5-10% of the capital cost

D : 15-20% of the capital cost

8. Selectivity can be expressed as

Options

A : ratio of the distribution coefficients in different solute

B : mass fraction of the solute in the extract phase at equilibrium

C : mass fraction of the solute in the raffinate phase

D : ratio of the mass fraction of the solute in the extract phase to the raffinate phase

9. Concentration polarization can be reduced further by

Options

A : pre filtering the solution

B : reducing the flow rate per unit membrane surface area

C : back washing periodically

D : all of the above

10. The solvent flux across the membrane can be expressed as (where A is the area, L p is the membrane permeability, ? is the reflection point, ? p is applied pressure and ?? is the osmotic pressure)

Options

A : J = L p (? p - ???)

B : J/A = L p (? p - ???)

C : J = L p /???

D : J/A = L p /? p

The disk centrifuge is the type of centrifuge used most often for bio separations due to its

Options

A : a. continuous operation

B : b. lesser cost

C : c. higher speed

D : d. ease in operation

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