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Disease Associated With Immune System Online Exam Quiz

Important questions about Disease Associated With Immune System. Disease Associated With Immune System MCQ questions with answers. Disease Associated With Immune System exam questions and answers for students and interviews.

1. Which of the Rous sarcoma virus has a homologous cellular protein?

Options

A : c-src

B : v-src

C : v-ha-src

D : v-ha-ras

2. Difficulties with somatic gene therapy arise from all of the following except

Options

A : GVHD caused by mature T cells in the transplanted cells

B : inserting a gene so that it will function properly

C : limited life span of more mature hematopoietic cells

D : transducing genetic material into stem cells

3. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

Options

A : activation of B cells by T-independent antigens

B : failure of B cells to provide co-stimulation for Th2 activation

C : failure of Th2 cells to provide co-stimulation for B cell isotype switching

D : failure of Th2 cells to provide co-stimulation for B cell proliferation

4. An autoimmune disease is

Options

A : AIDS

B : Measles

C : Lupus

D : Mumps

5. Specific translocations are associated with

Options

A : colon cancer

B : breast cancer

C : pancreatic cancer

D : some leukemias

6. Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

Options

A : CTL killing of viruses

B : dendritic cell activation to become a mature APC

C : infected cell processing of virus peptides

D : macrophage intracellular killing of bacteria

7. Infants are most susceptible to bacterial infection due to low circulating levels of IgG

Options

A : in utero (before birth)

B : at 0-3 months of age

C : at 3-12 months of age

D : at 12-24 months of age

8. Retinoblastoma is due to a mutation in a

Options

A : kinase

B : tumor supressor

C : cyclin

D : viral gene

9. DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

Options

A : knock-out mouse for RAG-1 and RAG-2

B : knock-out mouse for a thymus

C : nude mouse

D : recombinant mouse for CD3

1. If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

Options

A : alternative complement activation.

B : CD8 T cell-mediated cytotoxicity

C : macrophage activation to vesicular pathogens

D : IgG synthesis

2. The HIV virus infects primarily

Options

A : brain cells

B : cells in the immune system

C : red blood cells

D : liver cells

3. A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Options

A : Leu or Ileu

B : His or Pro

C : Tyr or Phe

D : Ser or Thr

4. The primary reason for AIDS, a deadly disease is that it

Options

A : is caused by a virus

B : is caused by a bacterium

C : destroys key components of the body's internal defense system

D : causes a breakdown of the body's inflammatory response

5. The chemical, typically released by the body in an allergic response is

Options

A : histamine

B : allergens

C : antihistamines

D : perforins

6. An example of an immunodeficiency disorder is

Options

A : thyroiditis

B : rheumatic fever

C : systemic lupus erythematosus

D : AIDS

7. To treat HIV infections using drugs, the major problem is that

Options

A : the drugs that are good inhibitors cannot by synthesized

B : the drugs interfere with normal digestion

C : the virus particles with altered (mutant) proteases arise

D : the drugs are rapidly degraded

8. A selective IgA deficiency would be expected to result in problems with

Options

A : bacterial infections

B : infections following dental work due to bacteria entering the bloodstream

C : mucosal pathogens

D : pathogens which can survive inside macrophages

9. Bone marrow given to an infant with SCID must

Options

A : be irradiated to eliminate GVHD

B : contain mature T cells that can begin making immune responses immediately

C : come from a donor that shares some MHC alleles with the recipient

D : come from one of the child's parents

10. Combined cellular and humoral immune deficiencies result from lack of all of the following except

Options

A : a thymus

B : class II MHC

C : HIV infection of CD4 + T cells

D : transporter of antigen peptides (TAP)

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